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. 2023 Feb 10;25:19. doi: 10.1186/s13058-022-01598-w

Fig. 7.

Fig. 7

METTL3 induces HR+HER2− BC apoptosis via the m6A-Bax/caspase-3/-8/-9 pathway. A and B METTL3 knockdown or overexpression influenced the expression levels of caspase proteins as indicated by the western blot assay. C and D BAX expression was depleted upon METTL3 knockdown but enhanced by METTL3 overexpression. E MeRIP with an anti-m6A antibody was performed in MCF-7 cells. The m6A modification on BAX mRNA was depleted upon METTL3 knockdown. F Schematic summarizing the role of METTL3 in modulating HR+HER2− BC progression