TABLE 4.

Between‐group comparisons

Side	Activation peak	Coordinates			z score	pFWE (peak)	Volume (k)	pFWE (cluster)	r
		x	y	z
Upregulate > permit
HC > FLE patients
L	Anterior cingulate cortex	−4	24	30	4.47	0.377	144	0.006	0.631
R	Paracingulate gyrus	4	24	40	3.62	1.000
L	IFG, triangular part	−58	26	4	4.40	0.452	136	0.008	0.680
L	Orbitofrontal cortex	−42	28	−4	3.51	1.000
L	"	−32	32	−2	3.48	1.000
L	Paracingulate gyrus	−2	46	30	4.07	0.864	109	0.025	0.640
L	Superior frontal gyrus	−4	54	34	4.01	0.912
L	Frontal pole	−6	54	46	3.24	1.000
L	Superior frontal gyrus	−10	8	66	3.61	1.000	82	0.084	0.637
L	"	−14	0	72	3.55	1.000
L	"	−10	18	68	3.54	1.000
L	Angular gyrus	−46	−60	24	3.94	0.950	98	0.041	0.620
L	Superior lateral occipital cortex	−58	−62	24	3.50	1.000
L	Anterior middle temporal gyrus	−54	0	−28	4.64	0.216	181	0.001	0.746
L	Anterior superior temporal gyrus	−46	−6	−18	4.23	0.676
L	Anterior middle temporal gyrus	−60	−6	−12	4.02	0.901
FLE patients > HC
R	Superior lateral occipital cortex	28	−62	40	4.04	0.887	98	0.041	−0.614
R	"	34	−66	32	3.94	0.951
Upregulate > downregulate
HC > FLE patients
L	Precuneus	−12	−48	36	4.24	0.673	135	0.008	0.624
L	Posterior cingulate cortex	−2	−52	34	3.65	0.999
Downregulate > upregulate
HC > FLE patients
L	Cerebellar white matter	−36	−54	−40	3.93	0.956	107	0.026	−0.689
L	Cerebellar cortex	−36	−62	−42	3.86	0.981

Abbreviations: FLE, frontal lobe epilepsy; HC, healthy controls; IFG, inferior frontal gyrus; L, left; R, right.