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Physicochemical and pharmacokinetic properties (Lipinski parameters) of compounds 3a–e.
| Compd. | MW | ROTB | HBA | HBD | Violations | MR | TPSA | Log P |
|---|---|---|---|---|---|---|---|---|
| 3a | 357 | 8 | 3 | 2 | 0 | 101 | 54.12 | 4.23 |
| 3b | 426 | 9 | 3 | 2 | 0 | 126 | 57.36 | 4.59 |
| 3c | 440 | 9 | 3 | 2 | 0 | 131 | 57.36 | 4.82 |
| 3d | 440 | 9 | 3 | 2 | 0 | 131 | 57.36 | 4.79 |
| 3e | 440 | 9 | 3 | 2 | 0 | 131 | 57.36 | 4.76 |
