Figure 1.

The site-specific antibody conjugation using payloads other than synthetic cytotoxins. The monoclonal antibody on the left is engineered by introducing different sites for selective coupling including specific amino acids, unnatural amino acids, short peptide tags, or modified glycans (middle). Different payloads, including non-cytotoxic compounds, proteins and peptides, nucleic acids, as well as glycans and lipids (right), are used for conjugation.