Table 4.

Site-specific antibody conjugations with siRNA.

Categories	Antibody Formats	Specific Site Used	Conjugation Chemistry	MOA of siRNA	References
Non-covalent complex with peptide or polymer	Fab, scFv	Protamine fused	Noncovalent complex	In vitro and in vivo gene knockdown	[106]
	scFv	Conjugated with Cys oligo-9 arginine	Noncovalent complex	Antiviral in vivo	[107]
	scFv	Protamine fused	Noncovalent complex	In vitro gene knockdown	[108]
	scFv	Protamine fused	Noncovalent complex	Antiviral in vivo	[109]
	Ab, Fab	Conjugated unnatural amino acid with cationic copolymer	Noncovalent complex	In vitro gene knockdown	[110]
	scFv	Protamine fused	Noncovalent complex	Anticancer	[111]
Direct conjugation	Ab	Cys	THIOMABTM	In vitro and in vivo gene knockdown	[112]
	Fab	Cys	Thiol-mediated conjugation	In vivo gene knockdown in muscle	[113]
	Nb	Cys	Thiol-mediated conjugation	In vitro gene knockdown	[114]
	Ab	Engineered Lys	Lys-β-lactam	In vitro gene knockdown	[115]