Table 5.
Bivariate and multivariate logistic regression analyses of ENE using surgically resected and biopsy specimens
| Bivariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|
| Odds ratio | 95% CI | p-value | SE | Odds ratio | 95% CI | p-value | |
| Resection specimens (n = 71) | |||||||
| pT3,4 | 6.466 | 1.346–31.058 | 0.011 | - | - | - | 0.230 |
| pDOI > 10 mm | 3.620 | 1.066–12.299 | 0.033 | - | - | - | 0.508 |
| Invasion pattern | 1.603 | 0.288–8.906 | 0.587 | - | - | - | - |
| DR-I | 3.046 | 0.972–9.543 | 0.050 | - | - | - | - |
| TB-H | 3.429 | 1.205–9.753 | 0.018 | - | - | - | - |
| TILs-L | 1.552 | 0.583–4.135 | 0.378 | - | - | - | - |
| MMP14 at the tumour nest (high) | 7.500 | 2.479–22.691 | < 0.001 | - | - | - | 0.058 |
| MMP14 in CAFs (positive) | 5.056 | 1.703–15.011 | < 0.01 | - | - | - | 0.536 |
| MMP14 co-scoring system (high-risk) | 8.986 | 2.921–27.642 | < 0.001 | 0.573 | 8.986 | 2.921–27.642 | < 0.001 |
| Biopsy specimens (n = 46) | |||||||
| cDOI > 10 mm | 7.200 | 0.824–62.937 | 0.046 | - | - | - | 0.183 |
| DR-I | 5.727 | 0.653–50.258 | 0.09 | - | - | - | - |
| TB-H | 2.000 | 0.458–8.725 | 0.35 | - | - | - | - |
| TILs-L | 0.250 | 0.047–1.344 | 0.09 | - | - | - | - |
| MMP14 at the tumour nest (high) | 9.091 | 1.654–49.965 | < 0.01 | - | - | - | 0.458 |
| MMP14 in CAFs (positive) | 23.400 | 2.626-209.279 | < 0.001 | - | - | - | 0.289 |
| MMP14 co-scoring system (high-risk) | 32.0000 | 4.953-206.762 | < 0.001 | 0.952 | 32.000 | 4.953-206.761 | < 0.001 |
CI, confidence interval; SE, standard error; pT, pathological T; pDOI, pathological depth of invasion; DR-I, immature desmoplastic reaction; TB-H, high tumour budding; TILs-L, low-grade tumour-infiltrating lymphocytes; CAFs, tumour-associated fibroblasts; cDOI, clinical depth of invasion. Boldface indicates statistically significant values