Table 6.

Performance of MMP14 expression as a predictor of extranodal extension

MMP14 expression	Sensitivity	Specificity	PPN	NPV	Accuracy	AUC	95% CI	p-value	Cohort proportion (no.; yes:no)
Surgically resected specimens
CAFs (positive)	78%	59%	46%	81%	66%	0.684	0.576–0.793	< 0.001	(39:32)
Tumour nest (high)	78%	68%	60%	83%	72%	0.730	0.6238–0.8358	< 0.01	(35:36)
Co-scoring system (high risk)	63%	84%	71%	79%	76%	0.735	0.628–0.843	< 0.01	(24:47)
Biopsy specimens
CAFs (positive)	90%	72%	47%	96%	76%	0.811	0.688–0.934	< 0.001	(19:27)
tumour nest (high)	80%	72%	42%	93%	72%	0.747	0.596–0.899	0.01	(19:27)
Co-scoring system (high-risk)	80%	89%	67%	94%	87%	0.844	0.704–0.985	< 0.01	(12:34)

PPV, positive predictive value; NPV, negative predictive value; AUC, area under the roc curve; CI, confidence intervals; CAFs, cancer-associated fibroblasts. Boldface indicates statistically significant values