Scheme 3.
Synthesis of the diethyl (aziridin-2-yl)methylphosphonate (RS)-33. Reagents and conditions: (a) NaN3, (NH4)2SO4, MeOH, reflux, 4 h, 95%; (b) PPh3, toluene, rt, 2 h; (c) reflux, 1 h, 53% from two steps.
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