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. 2023 Jan 21;15(3):570. doi: 10.3390/nu15030570

Figure 4.

Figure 4

Circulating parameters and HOMA-IR of O-CON, O-WD and O-REV male and female animals treated with vehicle or leptin during suckling and fed SD or WD from weaning, under fasting (at three and half months) and ad libitum (four months) feeding conditions. Data are mean ± SEM (n = 8–12). Statistics: After data separation depending on post-weaning diet, three-way ANOVA was performed to analyze the effect of sex, maternal diet and/or leptin treatment. In each sex, two-way ANOVA was performed to analyze the effect of leptin treatment and/or maternal diet. Single comparisons between leptin versus vehicle-treated rats of all experimental groups were carried out using Mann-Whitney U test. Symbols: sex (S), maternal diet (MD), leptin treatment (L); A ≠ B (p < 0.05, LSD post-hoc, two-way ANOVA); *, different from their vehicle-treated equal (p < 0.05, Mann-Whitney U test). Abbreviations: offspring of CON-dams (O-CON), offspring of WD-dams (O-WD), offspring of REV-dams (O-REV), vehicle (V), leptin (L).