Figure 8.

Summary of the effects of leptin supplementation during suckling on cumulative food intake (from one to four months of age), fat mass and hepatic lipid content (four months), and circulating parameters in adult O-CON, O-WD and O-REV male and female rats weaned onto SD or WD. Circulating parameter were determined at four months (under feeding conditions), or at three and a half months (under fasting conditions). Abbreviations: offspring of CON-dams (O-CON), offspring of WD-dams (O-WD), offspring of REV-dams (O-REV), standard diet (SD), western diet (WD). Symbols: ↑ and ↓ indicate increases or decreases, respectively, by Mann-Whitney U test, two-way ANOVA, or three-way ANOVA with respect to their vehicle-treated equals; ●, significant difference in the indicated group with respect to its vehicle-treated equal by Mann-Whitney U test.