Scheme 3.
Synthesis route of target compounds 19a-19b and 21a-21b. Reagents and conditions: (a) 3-chloro-3-methylbut-1-yne, CuCl2, DBU, CH3CN, 0 °C; (b) pyridine,120 °C; (c) n-BuLi, anhydrous THF, −78 °C; (d) PCC, CH2Cl2, rt.
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