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. 2022 Mar 21;11(6):432–441. doi: 10.4103/EUS-D-21-00178

Table 2.

Summary of studies on EUS chemoablation of pancreatic cystic lesions

Reference n Ablative agent Complete resolution (n) Partial resolution (n) Complications
Oh 2008 14 Ethanol lavage with paclitaxel injection 11 2 7% abdominal pain
43% hyperamylasemia
7% pancreatitis
Oh 2009 10 Ethanol lavage with paclitaxel injection 6 2 10% pancreatitis
Oh 2011 52 Ethanol lavage with paclitaxel injection 29 6 2% fever
2% pancreatitis
2% abdominal pain
2% splenic vein obstruction
DeWitt 2014 22 Ethanol lavage with paclitaxel injection 10 5 13% abdominal pain
10% pancreatitis
3% peritonitis
3% gastric wall cyst
Moyer 2016 10 (alcohol arm 4; alcohol-free arm 6) Saline or ethanol lavage followed by paclitaxel and gemcitabine injection 67% in saline arm versus
75% in ethanol arm
- Ethanol arm: 20% pancreatitis Saline arm: None reported
Kim 2017 36 (ethanol ablation 8; ethanol lavage with paclitaxel ablation 28) Ethanol ablation or ethanol lavage followed by paclitaxel injection 19 7 7% abdominal pain
7% pancreatitis
2% intracystic hemorrhage
Choi 2017 164 Ethanol lavage with paclitaxel injection 114 31 4% pancreatitis
1% psuedocyst
1% abscesses,
0% (1/164) risk of portal vein thrombosis, fever, splenic vein obstruction, pancreatic duct stricture Pericystic spillage, intracystic hemorrhage