Table 2.
Absolute counts of T-cell subsets in different age groups
| T-cell subsets (/μl) | Youngest old (61–70 years; n = 34) | Middle old (71–80 years; n = 53) | Oldest old (≥81 years; n = 40) | P-value |
|---|---|---|---|---|
| Lymphocytes | 1610.00 (1330.00–2015.00) | 1700.00 (1225.00–2010.00) | 1265.00 (935.00–1697.50) a,b | 0.021 |
| T cells (CD3+CD45+) | 1073.84 (852.36–1399.15) | 1044.12 (744.35–1284.32) | 717.04 (541.98–1145.76)a,b | 0.006 |
| CD4+ cells | 606.45 (402.20–790.92) | 525.41 (330.80–702.60) | 394.33 (225.58–594.15)a,b | 0.005 |
| CD8+ cells | 364.68 (305.35–580.17) | 426.50 (250.70–587.42) | 353.02 (203.69–493.26) | 0.435 |
| CD4+CD25+CD127dim+cells | 68.59 (52.95–92.38) | 65.17 (43.31–92.16) | 46.94 (29.45–76.72)a,b | 0.026 |
| CD4+CD28+ cells | 566.22 (350.45–706.50) | 491.41 (299.49–661.30) | 340.11 (185.80–524.67)a,b | 0.001 |
| CD4+CD28− cells | 27.91 (7.56–52.03) | 23.20 (10.48–55.78) | 36.60 (15.64–56.83) | 0.318 |
| CD4+CD45RA+ cells | 142.99 (80.18–256.00) | 113.43 (49.78–207.20) | 69.54 (36.65–125.28)a,b | <0.001 |
| CD4+CD45RA− cells | 412.05 (315.25–578.85) | 382.55 (266.81–524.69) | 289.56 (201.85–480.58)a | 0.011 |
| CD8+CD28+ cells | 216.72 (148.36–310.98) | 178.54 (144.36–289.30) | 139.36 (90.93–210.65)a,b | 0.007 |
| CD8+CD28− cells | 166.06 (97.00–244.66) | 194.77 (73.15–289.67) | 178.99 (102.83–270.51) | 0.686 |
| CD8+CD45RA+ cells | 157.12 (81.41–213.36) | 132.57 (100.07–197.54) | 123.89 (56.44–188.67) | 0.477 |
| CD8+CD45RA− cells | 214.26 (142.37–363.62) | 256.81 (138.32–350.78) | 199.18 (126.67–325.14) | 0.584 |
| CD4/CD8 ratio | 1.44 (1.06–2.00) | 1.31 (0.80–1.88) | 0.97 (0.70–1.59) | 0.037 |
Data are represented as median (interquartile range). P-value was calculated among the three groups and statistically significant P-values are marked in bold.
a P < 0.05 compared with the youngest-old group.
b P < 0.05 compared with the middle-old group.