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Mutations known to affect αS aggregation. αS sequence with segments colored as in Figure 2 and locations of mutations noted. Mutations above the sequence are either neutral (0 in Table 1, normal type) or accelerate aggregation (+1 in Table 1, bolded). Mutations below the sequence slow the sequence moderately (−1 in Table 1, normal type) or severely (−2 in Table 1, bolded).
