Table 1b.
Population Characteristics in Look AHEAD Genetic Sub-cohort for those completed Cardiorespiratory Fitness test (n=2,675)
| Characteristic | Total (n=2,675) |
DSE (n=1,308) |
ILI (n=1,367) |
|---|---|---|---|
| Women (%) | 1480 (55.3) | 709 (54.2) | 771 (56.4) |
| Ethnicity (%) | |||
| African American/Black | 416 (15.6) | 198 (15.1) | 218 (15.9) |
| American Indian/Alaskan native | 10 (0.4) | 3 (0.2) | 7 (0.5) |
| Asian/Pacific Islander | 23 (0.9) | 9 (0.7) | 14 (1.0) |
| White | 1,989 (74.4) | 975 (74.5) | 1,014 (74.2) |
| Other | 237 (8.9) | 132 (9.4) | 114 (8.3) |
| Hispanic (%) | 186 (7.8) | 94 (7.2) | 92 (6.7) |
| rs6265 near BDNF (%) | |||
| GG | 1,889 (70.6) | 928 (70.9) | 961 (70.3) |
| GA | 704 (26.3) | 340 (26.0) | 364 (26.6) |
| AA | 82 (3.1) | 40 (3.1) | 42 (3.1) |
| rs7279064 near C18orf2 (%) | |||
| TT | 1,279 (47.8) | 652 (49.8) | 627 (45.9) |
| TG | 1,097 (41.0) | 522 (39.9) | 575 (42.1) |
| GG | 299 (11.2) | 134 (10.2) | 165 (12.1) |
| rs978656 near DNAPTP6 (%) | |||
| AA | 83 (3.1) | 42 (3.2) | 41 (3.0) |
| GA | 712 (26.6) | 346 (26.5) | 366 (26.8) |
| GG | 1,880 (70.3) | 920 (70.3) | 960 (70.2) |
| rs10887741 near PAPSS2 (%) | |||
| CC | 335 (12.5) | 176 (13.5) | 159 (11.6) |
| TC | 1,118 (44.4) | 577 (44.1) | 611 (44.7) |
| TT | 1,152 (43.1) | 555 (42.4) | 597 (43.7) |
| Age (year) | 58.81 ± 6.67 | 58.73 ± 6.59 | 58.89 ± 6.74 |
| Body mass index (kg·m−2) | |||
| Baseline | 35.84 ± 5.77 | 35.72 ± 5.57 | 35.94 ± 5.96 |
| Year 1 | 34.00 ± 5.96 | 35.42 ± 5.68 | 32.64 ± 5.92 a |
| Year 4 | 34.79 ± 6.10 | 35.32 ± 5.97 | 34.29 ± 6.19 a |
| Cardiorespiratory Fitness (MET) | |||
| Baseline | 5.21 ± 1.53 | 5.20 ± 1.55 | 5.21 ± 1.51 |
| Year 1 | 5.86 ± 1.87 | 5.45 ± 1.66 | 6.25 ± 1.97 a |
| Year 4 | 5.25 ± 1.70 | 5.09 ± 1.59 | 5.40 ± 1.77a |
| Polygenic Score of Physical Activity | 5.38 ± 1.64 | 5.31 ± 1.64 | 5.44 ± 1.65 b |
Abbreviations: BMI, body mass index; DSE, diabetes support and education; ILI, intensive lifestyle intervention; PGS, polygenic score; DNAPTP6, DNA polymerase trans activated protein 6 gene; PAPSS2, 3’-phosphoadenosine 5’-phosphosulfate synthase 2 gene; C18orf2, chromosome 18 open reading frame 2 gene; and BDNF, Brain Derived Neurotropic Factor gene
a
p<0.001 (DSE vs ILI)
b
p=0.042 (DSE vs ILI)