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. Author manuscript; available in PMC: 2023 Feb 11.
Published in final edited form as: Psychosom Med. 2021 Jun 1;83(5):440–448. doi: 10.1097/PSY.0000000000000930

Table 2a.

Linear Mixed Effect Models: Self-reported Physical Activity regressed on Polygenic Score of Physical Activity

ß 95% CI p-value
Total sample
Model with no interaction term PGS −4 −33 ~ 25 0.79
Model with 2-way interaction term PGS*intervention −31 −88 ~ 26 0.28
Model with 3-way interaction term PGS*intervention*year1 −22 −107 ~ 64 0.62
PGS*intervention*year4 −13 −103 ~ 77 0.77
Effect modification: age
Model with 2-way interaction term PGS*age 4 0 ~ 8 0.05
Model with 3-way interaction term PGS*intervention*age −4 −12 ~ 5 0.39
Model with 4-way interaction term PGS*intervention*year1*age 11 −1 ~ 24 0.08
PGS*intervention*year4*age −2 −14 ~ 12 0.81

PGS, polygenic score; 1 unit increase in PGS roughly equates to one additional effect allele for higher physical activity. All models were controlled for age, sex, baseline body mass index, principal component 1 and principal component 2, and study sites as well as all subcomponents of the interaction terms (e.g., PGS*age included PGS and age separately).