Table 1.
Demographic and clinical features of patients with Lung cancer
| Controls(n = 29) | Early lung cancer (n = 39) | Advanced lung cancer (n = 36) | χ2/F/μ | pvalue | |
|---|---|---|---|---|---|
| gender | |||||
| male/female | 15/14 | 15/24 | 24/12 | 5.986 | 0.05a |
| Age(mean ± SD), year | 51.07 ± 9.67 | 55.59 ± 8.23 | 56.06 ± 8.99 | 3.059 | 0.051b |
| Smoking(%) | 10/29 | 9/39 | 16/36 | 3.84 | 0.147a |
| Tumor diameter (cm) (mean ± SD) | 1.62 ± 0.94 | 4.93 ± 2.35 | -8.103 | 0.000*c | |
| KPS score(mean ± SD) | 95.00 ± 7.77 | 96.15 ± 7.11 | 94.44 ± 6.95 | 0.568 | 0.568b |
| Years of education (mean ± SD) | 10.00 ± 3.67 | 8.95 ± 3.50 | 7.92 ± 4.89 | F = 2.102 | 0.127 |
| Pathological type | χ2 | ||||
| Squamous cell carcinoma | 7 | 13 | 7.396 | 0.092a | |
| Adenocarcinoma | 29 | 18 | |||
| Small Cell Lung Cancer | 3 | 5 | |||
| Tumor markers (25%,50%,75%) | Z | ||||
| CEA | 1.53, 2.25, 3.57 | 1.87,4.38, 10.33 | 446.50 | 0.007*d | |
| NSE | 9.60, 11.80, 13.40 | 11.75, 13.70,21.96 | 397.50 | 0.001*d | |
| CYFRA21-1 | 1,40, 2.00,2.60 | 2.625,4.500,7.025 | 223.00 | 0.000*d | |
| SCC | 0.70,0.80,1.00 | 0.72,1.10,1.47 | 493.00 | 0.026*d | |
Data are expressed as ‾x ± s, n (%) or Interquartile Range (P25,P50,P75). aThe P values are obtained by using the χ2 test. bThe P values are obtained by using one-way ANOVA. cThe P values are obtained by using two-sample t-test. dThe P values are obtained by the Kruskal–Wallis test. *P < 0.05 is considered significant. CEA, carcinoembryonic antigen. NSE, neuron-specific enolase. CYFRA21-1, cytokeratins21-1. SCC, squamous cell carcinoma antigen