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. 2023 Feb 11;14:778. doi: 10.1038/s41467-023-36462-8

Fig. 7. Phosphoproteomic analyses in three AEG subtypes.

Fig. 7

a Volcano plot showing the differential significance of phosphorylation sites. Red circles represent sites with increased phosphorylation (FDR < 0.01 and log2(fold change) > 1) and blue circles indicate downregulated phosphorylation sites (FDR < 0.01 and log2(fold change) < −1). b Enriched biological processes of differentially phosphorylated sites in each subtype. c Kinase enrichment of differentially phosphorylated sites in each AEG tumor subtype. P, Fisher’s exact test. Asterisks (*) represent statistical significance (P < 0.05). Kinase-phosphosubstrate regulatory networks in tumors of the S-I (d), S-II (e), and S-III (f) subtypes.