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. 2023 Feb 11;13:2452. doi: 10.1038/s41598-023-29287-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of different doses of OLE on behavioural parameters in rotenone-induced mouse model. Narrow Beam Test showed increase in narrow beam walking time in rotenone group (***p < 0.001) as compared to the control group. Whereas, after the treatment with OLE (16 and 32 mg/kg bwt), the walking time of mice to cross the beam was significantly decreased (***p < 0.001). Hanging test presented decrease in hanging time in rotenone intoxicated mice as compared to control(***p < 0.001) whereas, in OLE treated group (16 and 32 mg/kg bwt), hanging time was significantly reduced (***p < 0.001). Catalepsy Test exhibited the reduced latency time to change its unusual posture was associated with rotenone induced mice (***p < 0.001) than control. While, significant decrease in catalepsy was observed in OLE treated mice (16 and 32 mg/kg bwt) (***p < 0.001).In all these three behavioural parameters, the OLE doses of 8 mg/kg bwt. showed a less significant effect. (*p < 0.05). The one-way ANOVA was used to analyse the data, followed by the Newman-Keuls test. The mean ± SEM (n = 6) is used to depict the values.