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. 2023 Feb 11;13:2458. doi: 10.1038/s41598-023-29712-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Immunofluorescent staining and confocal microscopy showing colocalizations of γ-tubulin and TUBGCP2 complexes in mitotic cells, which implicate knockdown of DNMT1 and specific inhibition of HDAC1 & HDAC2 synergistically, inhibit mitosis by reducing physical association of γ-tubulin with TUBGCP2, thereby inhibiting formation of γ-tubulin small complex (γTuSC). Ultimately, microtubule nucleation does not occur to form mitotic spindle for which less number of mitotic cells were observed.