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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Alzheimers Dement. 2022 Aug 12;19(4):1216–1226. doi: 10.1002/alz.12761

FIGURE 2.

FIGURE 2

SPG7 gene body methylation associated with AD pathology. (A) UCSC genome browser view of the genomic landscape encompassing the targeted SPG7 region (chr16: 89,532,477 to 89,532,607). The whole region overlaps with one of the SPG7 exons. Of note, some SPG7 transcripts do not include this particular exon, revealing the existence of alternative splicing. (B) DNA methylation level at each of the 12 detected CpGs in the SPG7 gene; CpG sites significantly associated with amyloid β after correction for multiple testing (q < 0.05) are highlighted in orange, while the non-significant CpG site is highlighted in dark blue. (C) Association between mean methylation level in the SPG7 gene and amyloid β load. (D) Mean DNA methylation level in the SPG7 gene was inversely associated with its expression.