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. 2023 Mar;26(3):326–334. doi: 10.22038/IJBMS.2023.66724.14644

Figure 3.

Hind paw withdrawal thresholds of rats in each group. Sham: PBS stimulation was applied to the superior sagittal sinus (SSS). CM: Episodic stimulation of the dura by applying 3 µl of IS to SSS (once per day for 7 days). CM+a: 24 hr after the CM group was administered sample A. CM+b: 24 hr after the CM group was administered Sample B. CM+c: 24 hr after the CM group was administered Sample C. a: JingJiu; Sample b: Jijiu; Sample c: normal saline, at a dose of 0.025 l/kg. The hind paw withdrawal threshold decreased significantly in the Sham groups compared with the CM group (*** P<0.001, *P<0.05, Sham group vs CM group); CM vs CM+a group, CM vs CM+c group; NS, P>0.05; CM vs CM+b group, *P<0.05 (n = 24, n = 15, and n = 9 rats in each group. The graph shows the median and interquartile range

Figure 3

PBS: Phosphate-buffered saline; CM: Chronic migraine; NS: Normal saline; SSS: Superior sagittal sinus