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Characteristics of Monogenic Versus Complex Genetic Diseases
| Monogenic (Mendelian) | Polygenic (Complex) | |
|---|---|---|
| Allele/variant frequency | Rare | Can be common |
| Effect size of major driving gene | Large | Small |
| Penetrance | High | Low |
| Role of environment | Limited | Strong |
| Inheritance model | Mendelian | None apparent |
