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. 2023 Jan 16;15(1):123–134. doi: 10.21037/jtd-22-1859

Figure 2.

Figure 2

Bufalin enhances the radiosensitivity of NSCLC cells. (A) A549, H1299, and HCC827 cells were treated with bufalin in combination with and without radiation (2/4/6 Gy) and radiation alone for 48 hours; cell viability was assayed by CCK-8 assay (P<0.01 vs. untreated controls). (B) Radiation survival curves of untreated cells and bufalin treated cells after irradiation with 2, 4, and 6 Gy for 48 hours. The radiobiology parameters (D0, Dq, N, and SF2) and radiosensitivity ratios SERD0 of the 3 NSCLC cells were calculated using the formula SF =1 − (1 − e−D/D0)N. Data are the mean. Buf, bufalin; IR, infrared radiation; Buf, bufalin; SF2, survival fraction of 2 cGy irradiation dose; D0, mean lethal dose value; Dq, quasi-threshold dose; N, extrapolation number; SERD0, sensitivity enhancement ratio of D0; NSCLC, non-small cell lung cancer; CCK-8, Cell Counting Kit-8.