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. 2023 Jan 27;14:1095812. doi: 10.3389/fimmu.2023.1095812

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Copyright © 2023 Walaas, Gopalakrishnan, Bakke, Skovdahl, Flatberg, Østvik, Sandvik and Bruland

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell cluster specific transcriptome in 2% and 20% oxygen. Enrichment analysis of upregulated genes in the stem, progenitor, and differentiated cell clusters from 2% vs. 20% oxygen culture (adjusted P <0.05). were generated with MetaCore+MetaDrug™ version 21.3 build 70600 ( SF1 , sheets 12-15). The dot plots display how (A) genes related to cell cycle and mitosis (A), genes associated with cell adhesions and cell junctions (B), hypoxia-related genes (C) and barrier genes (D) were expressed in the different cell type clusters. Cell clusters are listed along the x-axis, while genes are listed along the y-axis. The color intensity represents mean expression within a cluster, and the radius of the dot represents the fraction of cells in the cluster expressing a gene. (E, F) Bars indicate –Log10 false discovery rate (FDR), while the y-axis lists top three GO processes upregulated in stem-like cell clusters (E) and differentiated cell cluster (F) in 2% compared to 20% oxygen culture ( Supplementary file SF1 , sheets 14 and 15, respectively).