Figure S6.

Antibody REGN10933 escape mapping using Delta deep mutational scanning libraries, related to Figures 1 and 3

(A) Total escape scores for each site within Delta spike and a zoomed-in plot showing key escape sites.

(B) Heatmap of mutation-escape scores at key sites. Residues marked with X are the wild-type amino acids in the Delta sequence. Amino acids not present in our libraries are shown in gray. An interactive version of this heatmap for the entirety of spike is at https://dms-vep.github.io/SARS-CoV-2_Delta_spike_DMS_REGN10933/REGN10933_escape_plot.html.

(C) Surface representation of spike colored by the sum of escape scores at that site. REGN10933 antibody is shown in green. PDB:6XDG and PDB: 6XM4 were aligned to make this figure. Site numbering in all plots is based on the Wuhan-Hu-1 sequence.