Figure 1.

Lower cold endurance of B6 compared to AJ warm-acclimated mice and rescue of the endurance by CA. Whole-body measurements were performed using AJ and B6 mice acclimated to a thermoneutral housing temperature (30 °C; WA) or to cold (6 °C; CA), at 33 °C and 5 °C, respectively, using different groups of mice; for n in various groups, see legend to S2 Table. (A and B) Core body temperature (T_b) of AJ (A) and B6 mice (B) measured at 33 °C (left part of the graphs) or at 5 °C (right part of the graphs); data for individual mice are plotted (for mean curves, see S1A and S1B Fig). (C and D) Oxygen consumption of AJ (C) and B6 mice (D) measured at 33 °C (left part of the graphs) or at 5 °C (right part of the graphs); data for individual mice are plotted (for mean curves, see S1C and S1D Fig). (E and F) Percent relative cumulative frequency (PRCF) of respiratory quotient (RQ) of AJ (E) and B6 mice (F); the PRCF curves pooled from RQ values from all animals in a given group. (G and H) Physical activity of AJ (G) and B6 (H) mice; mean curves for whole experimental group are plotted. See S2 Table for the mean values of the measured parameter, and the number of the animals.