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Description of two cohorts of HS rats used to measure IOP.
| Cohort | Males | Females | Total | Age, days (mean +SD) | Manipulations |
|---|---|---|---|---|---|
| Behavioral testing | 543 | 536 | 1,079 | 66.4 + 8.8 | The rats were tested for multiple behaviors and were exposed to nicotine via self-administration for 12 days. IOP was measured 10 days after the final dose of nicotine |
| Breeder | 363 | 370 | 733 | 170.1 + 47.1 | Female breeders had one, sometimes two litters, and were never exposed to nicotine |
