Figure 1.

Toxicant mixtures targeting Sertoli cells in testis. The zoom-in illustrates various testicular cell types, including Leydig and peritubular myoid cells in the interstitium, and in the seminiferous tubules, Sertoli cells and germ cells, from spermatogonia to subsequent spermatogenic cells resulting in spermatozoa, which are released in the lumen. Sertoli cells play a vital role during male gonad development and throughout spermatogenesis in adulthood, acting as “nurse cells” of germ cells. Thus, assessing the impact of EDC and drug exposures on these cells is important. Some of the mixtures discussed in this review are highlighted here. A dashed arrow suggests indirect effects of exposure to toxicant mixtures on Sertoli cells, whereas a solid arrow suggests direct effects of exposure to toxicant mixtures on Sertoli cells.