Table 5.
Basic characteristic, embryological outcomes and clinical outcomes of subgroups based on the trigger day FSH/LH ratio cutoff value for poor responders.
| Trigger day FSH/LH≤9.665 | Trigger day FSH/LH > 9.665 | P | |
|---|---|---|---|
| N | 854 | 595 | |
| AMH (ng/ml) | 4.43 ± 4.05 | 3.70 ± 3.01 | 0.041 a |
| Age (years) | 31.88 ± 4.03 | 31.66 ± 4.06 | 0.264 a |
| AFC | 12.98 ± 6.38 | 12.22 ± 4.92 | 0.140 a |
| BMI (kg/m2) | 22.60 ± 3.00 | 21.52 ± 2.64 | 0.000 a |
| Basal FSH (IU/L) | 7.99 ± 2.93 | 7.36 ± 2.19 | 0.001 a |
| Basal LH (IU/L) | 5.51 ± 3.89 | 4.07 ± 2.05 | 0.000 a |
| Basal E2 (pg/ml) | 43.39 ± 38.09 | 41.08 ± 29.40 | 0.355 a |
| Basal P4 (pg/ml) | 0.66 ± 0.87 | 0.70 ± 0.81 | 0.001 a |
| Basal FSH/LH ratio | 1.94 ± 1.47 | 2.16 ± 1.13 | 0.000 a |
| Trigger day FSH (IU/L) | 16.46 ± 6.00 | 19.97 ± 6.45 | 0.000 a |
| Trigger day LH (IU/L) | 4.09 ± 3.27 | 1.17 ± 0.57 | 0.000 a |
| Trigger day E2 (pg/ml) | 3835.08 ± 2933.23 | 4209.53 ± 2590.50 | 0.000 a |
| Trigger day P (pg/ml) | 1.04 ± 0.70 | 1.32 ± 1.02 | 0.000 a |
| Starting dose of Gn (IU) | 208.41 ± 57.28 | 223.03 ± 55.66 | 0.000 a |
| Stimulation duration of Gn (days) | 9.63 ± 1.79 | 9.98 ± 1.43 | 0.000 a |
| Total Gn (IU) | 2123.07 ± 786.24 | 2357.98 ± 713.68 | 0.000 a |
| EMBRYOLOGICAL OUTCOMES | |||
| No. of oocytes retrieved | 10.44 ± 5.95 | 11.76 ± 5.29 | 0.000 b |
| No. of fertilized oocytes | 8.14 ± 4.94 | 9.20 ± 4.58 | 0.000 b |
| No. of day 3 good quality embryos | 0.95 ± 1.49 | 0.90 ± 1.37 | 0.852 b |
| No. of total available embryos | 4.13 ± 3.14 | 4.21 ± 2.86 | 0.000 b |
| Maturation rate (%) | 1963/2341 (83.9%) | 1467/1759 (83.4%) | 0.698 c |
| Fertilization rate of IVF (2PN) (%) | 4873/6573(74.1%) | 3968/5240 (75.7%) | 0.048 c |
| Fertilization rate of ICSI (2PN) (%) | 1654/1963 (84.3%) | 1226/1467 (83.6%) | 0.588 c |
| Proportion of poor responders | 205/854 (24.0%) | 65/595(10.9%) | 0.000 c |
| FRESH EMBRYO TRANSFER | |||
| Number of cycles transferred | 306 | 200 | |
| Number of embryos transferred | 495 | 329 | |
| Endometrium thickness on trigger day (cm) | 1.07 ± 0.17 | 1.03 ± 0.15 | 0.007 a |
| P4 level on trigger day (pg/ml) | 0.90 ± 0.38 | 1.00 ± 0.41 | 0.003 a |
| Average number of embryos transferred | 1.62 ± 0.49 | 1.65 ± 0.48 | 0.534 a |
| Average score of cleavage embryos transferred | 7.23 ± 1.16 | 7.24 ± 1.18 | 0.877 a |
| Proportion of blastocyst embryo transfer (%) | 29/306 (9.50%) | 22/200 (11.0%) | 0.578 c |
| CLINICAL OUTCOMES | |||
| Implantation rate (%) | 168/495 (33.9%) | 83/329 (25.2%) | 0.008 c |
| Biochemical pregnancy rate (%) | 165/306 (53.9%) | 86/200 (43.0%) | 0.016 c |
| Clinical pregnancy rate (%) | 140/306 (45.8%) | 66/200 (33.0%) | 0.004 c |
| Ongoing pregnancy rate (%) | 118/306 (38.6%) | 52/200 (26.0%) | 0.003 c |
| Multiple pregnancy rate (%) | 35/306 (11.4%) | 17/200 (8.50%) | 0.287 c |
| Live birth rate (%) | 118/306 (38.6%) | 52/200 (26.0%) | 0.004 c |
| Abortion rate (%) | 17/140 (12.1%) | 12/66 (18.2%) | 0.245 c |
| Ectopic pregnancy rate (%) | 5/140 (3.60%) | 2/66 (3.00%) | 0.841 c |
Data is expressed as mean ± SD, or number (percentage); AMH, anti-Müllerian hormone; AFC, antral follicles count; P4, progesterone; No., Number.
a
Student’s t-test or Mann-Whitney U test.
b
Adjusted for confounding factors (AMH, BMI, starting dose of Gn and Total Gn).
c
Chi-test or Fisher’s exact test.