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. 2023 Jan 30;12:1002186. doi: 10.3389/fonc.2022.1002186

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Copyright © 2023 Li, Wang, Zhang, Dong, Cai, Huang and Dong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of multi-omics data showed that PKMYT1 was over-expressed in BC and could serve as an independent prognostic marker. (A, B) The PKMYT1 mRNA expression levels in BC microarray data and paired TCGA-BRCA cohort; (C) The mRNA expression levels of PKMYT1 in local cohort sample; (D) DNA methylation levels of PKMYT1 between BC and normal tissues were analyzed using HM450 chip sequencing data of TCGA-BRCA cohort; (E, F) The correlation between PKMYT1 mRNA expression level and PKMYT1 copy number variation or methylation level in TCGA-BRCA cohort; (G–J) Kaplan-Meier analysis for RFS and OS of BC patients in the KM-plotter cohort and METABRIC cohort; (K) Univariate and multivariate Cox regression analysis for OS of BC patients in METABRIC cohort.