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. 2023 Jan 30;14:1055671. doi: 10.3389/fimmu.2023.1055671

Figure 2.

Figure 2

DSP-0509 induced systemic cytokine response in TLR7 dependent manner (A) CT26 cell-bearing Balb/c mice were treated with 1 mg/kg of DSP-0509 intravenously. Blood was collected after 2 h, 6 h, and 24 h respectively and the concentration of cytokines were measured by the Luminex assay. The values are the mean of 4 independent studies. (B) TLR7 KO mice or wild-type Balb/c mice were treated with 5 mg/kg of DSP-0509 intravenously. Blood was collected after 2 h and the concentration of IFNα was measured by ELISA and other cytokines were measured by the Luminex assay. The values are the mean ± S.E.M. of each group. (C) Balb/c mice were treated with 5 mg/kg of DSP-0509 intravenously at day 0 as a first dose and on day 1, 3, 7, or 14 as the second administration, and whole plasma was collected 2 h after the last administration. Plasma IFNα was measured by ELISA. The values are the mean ± S.E.M. of each group (n=5/group).