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MSOT principle of operation and common analysis framework. Left: Preclinical MSOT imaging of the liver and validation by cryoimaging. Right: Clinical MSOT imaging of the liver and validation by ultrasound. The common analysis framework includes the intensity and spectral analysis. USD: Ultrasound detector, NIL: Near-infrared light, US: Ultrasound, WT: Water tank, HHP: Hand-held probe, NI: Near-infrared. The coverage angle in preclinical MSOT is 270° and in hand-held clinical MSOT 140°.
