Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 30;14:1118781. doi: 10.3389/fimmu.2023.1118781

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Qian, Yu, Liu, Cai, Manjili, Yang, Guo and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

SRA knockdown by chitosan-SRA siRNA complex in vitro and in vivo. (A) Screening of small-interfering RNAs (siRNAs) in complex with chitosan for effective downregulation of SRA expression in DC1.2 cell line. (B) Validation of SRA downregulation in bone marrow-derived DCs following treatment with the chitosan-SRA siRNA nanoparticle complex. Representative flow cytometry results and quantification of SRA-expressing DCs are shown. (C) C57BL/6 mice were injected with chitosan-SRA siRNA complex (5 μg/mouse) on days 0 and 2. Cells in lavage fluid were collected on day 5 and analyzed for SRA expression on CD11c⁺ cells. *p < 0.05.