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. 2023 Jan 30;14:1118781. doi: 10.3389/fimmu.2023.1118781

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Copyright © 2023 Qian, Yu, Liu, Cai, Manjili, Yang, Guo and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Targeting SRA using chitosan-siRNA complex augments chaperone vaccine-induced antitumor immunity. (A, B). C57BL/6 mice (n=5) established with experimental lung metastases were treated with chitosan-SRA siRNA and hsp100-gp100 chaperone vaccine as described in the scheme of experimental procedure. Gross images of lungs (A) and the number of metastatic nodules (B) are shown. (C) Tumor-infiltrating cells were analyzed for IFN-γ-expressing CD8⁺ or CD4⁺ T cells. (D) Tumor tissues from treated mice were examined for immune-related gene expression as indicated. (E) Flow cytometry analysis of the frequency of IL-12p70⁺CD11c⁺ cells. The data are representative of three independent experiments with similar results. *p < 0.05; **p < 0.01.