Table 2.
Immunohistochemistry patterns for MMR proteins among tested individuals.
| n (%) | |
|---|---|
| Typical IHC patterns a | 596 (84.8) |
| MLH1/PMS2 | 265 (37.7) |
| MSH2/MSH6 | 103 (14.7) |
| MSH6 | 92 (13.1) |
| PMS2 | 72 (10.2) |
| MLH1 | 40 (5.7) |
| MSH2 | 24 (3.4) |
| Atypical IHC patterns b | 107 (15.2) |
| MLH1/MSH2/MSH6/PMS2 | 34 (4.8) |
| MLH1/MSH6/PMS2 | 17 (2.4) |
| MSH6/PMS2 | 23 (3.3) |
| MLH1/MSH2 | 8 (1.1) |
| MLH1/MSH2/MSH6 | 10 (1.4) |
| MSH2/MSH6/PMS2 | 7 (1.0) |
| MLH1/MSH2/PMS2 | 4 (0.6) |
| MLH1/MSH6 | 2 (0.3) |
| MSH2/PMS2 | 2 (0.3) |
| Total | 703 |
a
Typical patterns involved only one of the two MMR heterodimers (MSH2/MSH6 or MLH1/PMS2).
b
Atypical patterns involved two or three MMR proteins that were from both MMR heterodimer pairs.
IHC, immunohistochemistry; MMR, mismatch repair.