Table 6.

Germline MMR gene VUS that were reclassified and patients affected by reclassification.

	Consistent IHC in ≥ 1 Patient	Consistent IHC in ≥ 2 Patient
Unique variants
Total	103	17
Downgraded to Benign/Likely Benign, N (%)	35 (34.0%)	12 (70.6%)
Upgraded to Pathogenic/Likely Pathogenic, N (%)	14 (13.6%)	3 (17.6%)
Total patients with expected MMR variants (includes multiple observations of the same variant)
Total	121	45
Downgraded to Benign/Likely Benign, N (%)	57 (47.1%)	35 (77.8%)
Upgraded to Pathogenic/Likely Pathogenic, N (%)	17 (14.0%)	6 (13.3%)