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. 2023 Jan 30;11:1117647. doi: 10.3389/fbioe.2023.1117647

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Copyright © 2023 Sun, Cui, Yuan, Dou, Wang, Xu, Wang, Yin, Wu and Peng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tetra-PEG hydrogel-based aspirin sustained release system with beneficial effects on bone regeneration (Zhang et al., 2019). (A) Scheme of the synthesis procedure for ASA-PEG hydrogels. (B) μCT (left), H&E (upper), and Masson staining (lower) images of mice calvaria bone structure, (C) untreated experimentally induced calvaria bone defects, (D) calvaria bone defects after transplantation of PDLSCs and PEG hydrogels, and (E) calvaria bone defects after transplantation of PDLSCs and PEG-ASA hydrogels. The yellow arrows in (C–E) indicate the margins of bone defects, and the white arrows indicate new bone. The white dotted line defines the bone defect area. ASA, acetylsalicylic acid; PDLSCs, periodontal ligament stem cells; H&E, hematoxylin and eosin; μCT, micro-computed tomography. Copyright ^© 2019 Zhang, Ding, Zhang, Sun, Han, and Yu. Reproduced with permission from FRONTIERS MEDIA SA.