Table 2.

Factors change related to Alzheimer’s Disease.

Factors	Human	Animal	Strength of Evidence
			Human	Animal
Aβ	↓ [ 46 , 29 ]	↓ [ 46 ]	Poor	Strong
tau protein	-	-	-	-
MAPKs	↑ [ 46 , 53 ]	-	-	Fair
GFAP	↑ [ 28 , 29 , 43 , 42 ]	↑ [ 35 ]	Poor
HightMBP	-	↓ [ 28 ]	-	Poor
NF-L	-	↓ [ 28 ]	-	Poor
NADPH oxidase	-	↓ [ 46 ]	-	Poor
Apoptotic	-	↑ [ 52 , 44 ]	-	Poor
CBF	-	↑ [ 29 ]	-	Poor
Brain temperature	-	↑ [ 29 ]	-	Poor
Neuronal activity	-	↑ [ 29 ]	-	Poor
α-syn	↑ [ 48 ]	-	Poor	-
Oxidative stress	↑ [ 48 ]	-	Poor	Poor
BBF	↑ [ 46 ]	-	Poor	-

Aβ: Amyloid-beta peptide, MAPK: Mitogen-activated protein kinases, GFAP: Glial fibrillary acidic protein, CBF: Cerebral blood flow, NADPH: Nicotinamide adenine dinucleotide phosphate, MBP: Myelin basic protein, NF-L: Neurofilament-L, BBF: Blood-Brain Flow, up and down arrows show increase and decrease, respectively