Figure 5.

CAR-IL15f T cells are superior to CAR.IL15s and conventional CAR T in mediating survival of mice in syngeneic models of glioma. (A) Survival analysis of mice bearing CT2A-IL13Rα2 glioma and treated with 1×10⁶ of CAR T cells (n=10, *p<0.05). (B) Mice surviving long-term were rechallenged with parental CT2A line (**p<0.01). (C) Survival analysis of mice bearing GL261-IL13Rα2 glioma and treated with 1×10⁶ of CAR T cells (n=10, *p<0.05). (D) Mice surviving long-term were rechallenged with parental Gl261 line. (E) Morphometric analysis of tumor area in the brain of mice bearing GL261-IL13Rα2 glioma tumors 10 days after the treatments of CAR T cells (n=5/group, *p<0.05, *** p<0.001), and representative images of H&E stain of the brain of mice after CAR T cell treatment. CAR, myeloid-derived suppressor cell; NT, non-transduced.