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. 2023 Jan 26;13:976945. doi: 10.3389/fonc.2023.976945

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Copyright © 2023 Decotret, Shi, Thomas, Hsu, Pallen and Bennewith

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images displaying potential interactions between alpha-smooth muscle actin (αSMA)-positive vasculature and glial fibrillary acidic protein (GFAP)-positive astrocytes within the brain environment. (A) High resolution confocal images of GFP-tagged LN229 GBM spheroids invading into murine brain tissue sections stained for GFAP (astrocytes in pink) and αSMA (vasculature in red). The boxed region is enlarged to the right of the image. Scale bar = 200 µm. (B) High resolution confocal images of GFP-tagged LN229 GBM spheroids invading into murine brain tissue sections stained for GFAP (astrocytes, pink). The boxed region is enlarged to the right of the image. Scale bar = 200 µm.