. 2022 Aug 25;1(1):23–35. doi: 10.1515/nipt-2022-0009

Table 1:

Overlapping Molecules between the GSE47474 dataset and Molecules Associated with IRF7.

Molecule	Prefrontal cortex	Striatum	Hippocampus	Entrez gene name	Molecular family
ACADS	✓	✓		Acyl-CoA dehydrogenase short chain	Enzyme
ACKR2	✓			Atypical chemokine receptor 2	G-protein coupled receptor
ADAR	✓			Adenosine deaminase RNA specific	Enzyme
Ccl2	✓			Chemokine (C-C motif) ligand 2	Cytokine
CD69^a	✓			CD69 molecule	Transmembrane receptor
CREBBP^a	✓			CREB binding protein	Transcription regulator
CSF1	✓			Colony stimulating factor 1	Cytokine
CXCL10^a	✓			C-X-C motif chemokine ligand 10	Cytokine
DHX58		✓	✓	DExH-box helicase 58	Enzyme
DYNC1H1	✓			Dynein cytoplasmic 1 heavy chain 1	Peptidase
EFNA5^a	✓			Ephrin A5	Kinase
EMX1	✓			Empty spiracles homeobox 1	Transcription regulator
EP300^a	✓	✓		E1A binding protein p300	Transcription regulator
FLT3	✓			fms related receptor tyrosine kinase 3	Kinase
GBP6	✓			Guanylate binding protein family member 6	Enzyme
HELZ2		✓		Helicase with zinc finger 2	Nucleus
IFI44			✓	Interferon induced protein 44	Other
IFIT3			✓	Interferon induced protein with tetratricopeptide repeats 3	Other
IFNG^a	✓			Interferon gamma	Cytokine
Igtp			✓	Interferon gamma induced GTPase	Enzyme
IL2RG	✓			Interleukin 2 receptor subunit gamma	Transmembrane receptor
IQSEC1	✓			IQ motif and Sec7 domain ArfGEF 1	Other
IRF7^a	✓	✓	✓	Interferon regulatory factor 7	Transcription regulator
INSR			✓	Insulin receptor	Kinase
KL		✓		Klotho	Enzyme
Ly6a	✓			Lymphocyte antigen 6 complex, locus A	Other
MAP3K7			✓	Mitogen-activated protein kinase kinase kinase 7	Kinase
MAP3K8^a	✓			Mitogen-activated protein kinase kinase kinase 8	Kinase
MMP2		✓		Matrix metallopeptidase 2	Peptidase
MX1	✓	✓	✓	MX dynamin-like GTPase 1	Enzyme
Mx2		✓		MX dynamin like GTPase 1	Enzyme
NCOA2^a			✓	Nuclear receptor coactivator 2	Transcription regulator
NSD2		✓		Nuclear receptor binding SET domain protein 2	Enzyme
OAS1	✓	✓	✓	2′-5′-oligoadenylate synthetase 1	Enzyme
OAS2	✓		✓	2′-5′-oligoadenylate synthetase 2	Enzyme
OASL	✓			2′-5′-oligoadenylate synthetase like	Enzyme
OASI2	✓	✓	✓	2′-5′ oligoadenylate synthetase-like 2	Enzyme
PARP12	✓			poly(ADP-ribose) polymerase family member 12	Enzyme
PARP14	✓	✓	✓	poly(ADP-ribose) polymerase family member 14	Enzyme
PDLIM2		✓		PDZ and LIM domain 2	Other
PGR^a	✓			Progesterone receptor	Ligand-dependent nuclear receptor
PMAIP1	✓			Phorbol-12-myristate-13-acetate-induced protein 1	Other
PSEN1^a	✓			Presenilin 1	Peptidase
PSMB10	✓			Proteasome 20S subunit beta 10	Peptidase
PSME1		✓		Proteasome activator subunit 1	Peptidase
PTGER4	✓			Prostaglandin E receptor 4	G-protein coupled receptor
PRL		✓		Prolactin	Cytokine
RSAD2	✓	✓	✓	Radical S-adenosyl methionine domain containing 2	Enzyme
RTP4	✓	✓	✓	Receptor transporter protein 4	Other
SAMSN1	✓			SAM domain, SH3 domain and nuclear localization signals 1	Other
SATB1	✓			SATB homeobox 1	Transcription regulator
SPP1	✓			Secreted phosphoprotein 1	Cytokine
STAT2^a	✓			Signal transducer and activator of transcription 2	Transcription regulator
STAT6^a	✓	✓		Signal transducer and activator of transcription 6	Transcription regulator
TLR3		✓		Toll like receptor 3	Transmembrane receptor
TLR5			✓	Toll like receptor 5	Transmembrane receptor
TRAF1	✓			TNF receptor associated factor 1	Other
TUBA1C	✓	✓		Tubulin alpha 1c	Other
UBA7			✓	Ubiquitin like modifier activating enzyme 7	Enzyme
USP18	✓	✓	✓	Ubiquitin specific peptidase 18	Peptidase
✓ Indicates the IRF7-associated molecules identified for each brain region

^aIndicates molecules associated with IRF7 with a significance of p=0.005 for every brain region identified.