Table 2:
Change in Z Score of Significant Canonical pathways in the Presence of IRF7 and its associated molecules.
| Canonical pathway | Categorization of canonical pathway | −Log(p-Value) | Change in Z-Score |
|---|---|---|---|
| 2a: Prefrontal cortex | |||
| Opioid signaling pathway | Neurotransmission | 12.8 | 0.239 |
| Dopamine-DARPP32 feedback in cAMP signaling | Neurotransmission | 12.3 | 0.120 |
| Synaptogenesis signaling pathway | Neuronal survival | 10.10 | 0.202 |
| Calcium signaling | Neurotransmission | 9.07 | 0.256 |
| Estrogen receptor signaling | Neurotransmission | 9.93 | 0.469 |
| Synaptic long-term potentiation | Neuronal survival | 9.89 | 0.322 |
| Senescence pathway | Neuronal survival | 8.58 | 0.268 |
| Neuroinflammation signaling pathway | Neuronal survival | 7.45 | −0.181 |
| VDR/RXR activation | Neurotransmission | 6.31 | −0.700 |
| Th1 pathway | Immune | 6.45 | 0.114 |
| Th2 pathway | Immune | 6.28 | −0.387 |
| Xenobiotic metabolism AHR signaling pathway | Immune | 6.10 | 1.216 |
| 2b: Striatum | |||
| IL-17 signaling | Immune | 8.51 | 2.449 |
| Xenobiotic metabolism CAR signaling pathway | Immune | 8.30 | 1.342 |
| Pulmonary healing signaling pathway | Neurotransmission | 7.31 | 2.236 |
| Estrogen receptor signaling | Neurotransmission | 6.65 | 2.449 |
| 2c: Hippocampus | |||
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza | Immune | 6.646 | 2.646 |
| Neuroinflammation signaling pathway | Neuronal survival | 6.488 | 2.121 |
| Phagosome formation | Immune | 6.177 | 2.673 |
| CREB signaling in neurons | Neuronal survival | 5.147 | 3.464 |
| 2d: GSE152461 dataset (prefrontal cortex) | |||
| Dopamine-DARPP32 feedback in cAMP signaling | Neurotransmission | 10.89 | 0.720 |
| CREB signaling in neurons | Neuronal survival | 9.24 | 0.330 |
| Synaptic long term depression | Neuronal survival | 9.60 | −0.165 |
| Role of PKR in interferon induction and antiviral response | Immune | 9.42 | 0.905 |
| Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza | Immune | 8.64 | 2.646 |
| Adrenomedullin signaling pathway | Immune | 7.43 | −0.482 |
| Calcium signaling | Neurotransmission | 7.28 | 0.278 |
| Estrogen receptor signaling | Neurotransmission | 7.13 | 0.469 |
| Synaptic long term potentiation | Neuronal survival | 6.89 | 0.322 |
| Senescence pathway | Neuronal survival | 6.58 | 0.268 |
| Neuroinflammation signaling pathway | Neuronal survival | 6.34 | −0.181 |
| VDR/RXR activation | Neurotransmission | 6.31 | −0.700 |
| Th1 pathway | Immune | 6.45 | 0.114 |