FIGURE 3.

ADTKD in the UK. (A) Major UK centres (with family numbers) from which ADTKD families have been recruited into the RaDaR and Genomics England 100 000 Genomes Project. (B) UMOD mRNA (NM_003361) and exon structure with UTR in grey. Protein domains are shown in colour code. UMOD mutations detected in the recruited families are presented above the mRNA structure with respect to their location and with disc size reflecting family numbers. For five families, the exact UMOD mutations were not recorded.