Table 3.
Population estimates for the final PK model
| Parameter | Estimate (RSE%) | IIV (CV%) (RSE%) | IOV (CV%) (RSE%) |
|---|---|---|---|
| Clearance (L/day) | 0.163 (7.5) | 43.4 (11.4) | 34.4 (5.2) |
| Volume of distribution (L) | 6.42 (5.9) | 37.1 (12.5) | |
| Maximum rate (Vmax) (mg/day) | 29.6 (7.0) | ||
| Plasma concentration for 50% of maximum rate (Km) (mg/L) | 37.9 (18.7) | ||
| Additional error (mg/L) | 4.33 (46.3) | ||
| Proportional error Radboud Sanquin |
0.0247 (3.7) 0.248 (32.4) |
RSE, relative standard error; IIV, interindividual variability; IOV, interoccasion variability.