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Population estimates for the final sequential PK–PD model
| Parameter | Estimate(RSE%) | IIV (CV%) (RSE%) |
|---|---|---|
| Baseline CP activity (%) | 100.7 (6.2) | 23 (19.2) |
| Maximum inhibition (Imax) | 0.96 (0.2) | |
| Plasma IC50 (mg/L) | 22.0 (8.6) | 38.5 (16.2) |
| Hill coefficient (γ) | 5.42 (4.6) | |
| Proportional error | 0.089 (3.7) |
RSE: relative standard error; IIV, interindividual variability.
