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. 2023 Jan 24;73(728):e211–e219. doi: 10.3399/BJGP.2022.0181

Table 2.

Drug classes implicated in ADRs according to the WHO-ATC classification system (n = 159 study participants)

WHO-ATC class ADRs, n % all ADRs
A Alimentary tract and metabolism 18 8.53
A02 Drugs for acid-related disorders 10 4.74
A07 Antidiarrhoeal, intestinal anti-inflammatory/anti-infective agents 1 0.47
A10 Drugs used in diabetes 5 2.37
A11 Vitamins 1 0.47
A12 Mineral supplements 1 0.47

B Blood and blood forming organs 4 1.90
B01 Antithrombotic agents 3 1.42
B03 Antianaemic preparations 1 0.47

C Cardiovascular system 69 32.70
C01 Cardiac therapy 5 2.37
C02 Antihypertensives 2 0.95
C03 Diuretics 13 6.16
C07 Beta blocking agents 4 1.90
C08 Calcium channel blockers 17 8.06
C09 Agents acting on the renin-angiotensin system 19 9.00
C10 Lipid-modifying agents 9 4.27

G Genito-urinary system and sex hormones 10 4.74
G04 Urologicals 10 4.74

H Systemic hormonal preparations, excluding sex hormones and insulins 4 1.90
H03 Thyroid therapy 3 1.42
H05 Calcium homeostasis 1 0.47

J Anti-infectives for systemic use 26 12.32
J01 Antibacterials for systemic use 26 12.32

L Antineoplastic and immunomodulating agents 1 0.47
L04 Immunosuppressants 1 0.47

M Musculoskeletal system 14 6.64
M01 Anti-inflammatory and antirheumatic products 10 4.74
M05 Drugs for treatment of bone diseases 4 1.90

N Nervous system 61 28.91
N01 Anaesthetics 4 1.90
N02 Analgesics 28 13.27
N03 Antiepileptics 7 3.32
N04 Anti-Parkinson’s drugs 1 0.47
N05 Psycholeptics 4 1.90
N06 Psychoanaleptics 16 7.58
N07 Other nervous system drugs 1 0.47

R Respiratory system 4 1.90
R03 Drugs for obstructive airway diseases 2 0.95
R06 Cough and cold preparations 2 0.95

ADR = adverse drug reaction. WHO-ATC = World Health Organization Anatomical Therapeutic Code.