Table 3.
Unadjusted (n= 592) and adjusted (n = 555) logistic regression for at least one ADR over 6 years (2010–2016)
| Characteristic | Unadjusted | Adjusted | ||
|---|---|---|---|---|
|
| ||||
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Age | 1.04 (0.99 to 1.08) | 0.09 | 1.00 (0.95 to 1.05) | 0.87 |
|
| ||||
| Deprivation | 1.05 (0.98 to 1.13) | 0.17 | 1.07 (0.98 to 1.16) | 0.15 |
|
| ||||
| Sex, female | 2.34 (1.59 to 3.44) | <0.001a | 1.83 (1.17 to 2.85) | 0.008b |
|
| ||||
| Private health insurance | 0.96 (0.67 to 1.38) | 0.83 | 1.33 (0.86 to 2.07) | 0.20 |
|
| ||||
| Medication adherence, MPR ≥80% c | 0.88 (0.60 to 1.31) | 0.54 | 0.81 (0.53 to 1.22) | 0.31 |
|
| ||||
| Marital statusd | 0.03b | |||
| Separated/divorced | 0.86 (0.34 to 2.18) | 0.75 | 0.76 (0.29 to 1.99) | 0.57 |
| Widowed | 1.83 (1.21 to 2.77) | 0.004b | 1.36 (0.84 to 2.20) | 0.22 |
| Never married/single | 1.31 (0.77 to 2.22) | 0.32 | 1.21 (0.67 to 2.17) | 0.52 |
|
| ||||
| Charlson comorbiditye | 0.28 | |||
| 1 | 1.42 (0.92 to 2.17) | 0.11 | 1.22 (0.76 to 1.95) | 0.41 |
| ≥2 | 1.09 (0.68 to 1.75) | 0.72 | 0.97 (0.57 to 1.65) | 0.90 |
|
| ||||
| VES ≥3 | 1.74 (1.18 to 2.56) | 0.005b | 1.22 (0.77 to 1.96) | 0.40 |
|
| ||||
| Polypharmacyf | <0.001a | |||
| 5–9 drug classes | 2.00 (1.33 to 3.01) | 0.001b | 1.81 (1.17 to 2.82) | 0.008b |
| ≥10 drug classes | 4.78 (2.55 to 8.95) | <0.001a | 3.33 (1.62 to 6.85) | 0.001b |
a
P<0.001.
b
P<0.05.
c
Missing data (n = 35 cases).
d
Referent married, missing data (n = 1 case).
e
Referent 0, missing data (n = 1 case).
f
Referent 0–4 drug classes. ADR = adverse drug reaction. MPR = medication possession ratio. OR = odds ratio. VES = Vulnerable Elders Scale.