TABLE 3.
Spearman correlations (r) by protein class for proteins measured with both the Olink and SOMAscan7K proteomics profiling platforms among 39 Nurses’ Health Study II participantsa
| Protein molecular function class | N | Median (Min, Max) | r < 0.40 | r = 0.40–0.75 | r > 0.75 |
|---|---|---|---|---|---|
| Cytokine | 74 | 0.50 (−0.19, 0.92) | 35.1 | 50.0 | 14.9 |
| Growth factor | 53 | 0.40 (−0.10, 0.94) | 50.9 | 35.9 | 13.2 |
| Dimer-forming | 72 | 0.39 (−0.23, 0.85) | 51.4 | 38.9 | 9.7 |
| Kinase | 49 | 0.43 (−0.15, 0.83) | 44.9 | 49.0 | 6.1 |
| Transferase | 28 | 0.33 (−0.25, 0.76) | 60.7 | 35.7 | 3.6 |
| Receptor | 193 | 0.39 (−0.24, 0.90) | 50.8 | 37.3 | 11.9 |
| Protease | 79 | 0.58 (−0.33, 0.95) | 32.9 | 43.0 | 24.1 |
| Protease inhibitor | 37 | 0.59 (−0.41, 0.94) | 35.1 | 40.5 | 24.3 |
| Hormone | 21 | 0.42 (−0.14, 0.95) | 42.9 | 33.3 | 23.8 |
| Structural | 30 | 0.39 (−0.24, 0.90) | 53.3 | 40.0 | 6.7 |
| Carbohydrate binding | 49 | 0.53 (−0.25, 0.90) | 40.8 | 40.8 | 18.4 |
| Peptide binding | 24 | 0.43 (−0.23, 0.89) | 45.8 | 33.3 | 20.8 |
| Lipid binding | 18 | 0.41 (−0.08, 0.91) | 44.4 | 44.4 | 11.1 |
| Transcription factor | 10 | 0.31 (0.01, 0.77) | 50.0 | 40.0 | 10.0 |
| Other/unclassified | 261 | 0.43 (−0.43, 0.96) | 44.4 | 40.6 | 14.9 |
| All proteins | 817 | 0.45 (−0.43, 0.96) | 44.8 | 40.5 | 14.7 |
Min, minimum; Max, maximum.
a
Estimated correlations are derived from overlapping participants in the Olink and SOMAscan7K within-person reproducibility pilots, accounting for repeated measures of protein concentrations approximately 1 year apart.