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. 2023 Jan 24;14(2):211–216. doi: 10.1021/acsmedchemlett.2c00504

Table 4. Identification of the Enzyme Targeted by the Inhibitors.

  IC50 (μM)a
  NADH-Q1 succinate-cytochrome c
32 0.040 >20
35 0.026 >20
a

IC50 values are the molar concentrations needed to reduce the control NADH-Q1 oxidoreductase activity or succinate-cytochrome c oxidoreductase activity in SMPs by 50%. Data are average values of at least two independent measurements.